E3 ubiquitin-protein ligase HOS1 (HOS1), Recombinant Protein
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E3 ubiquitin-protein ligase HOS1 (HOS1), Recombinant Protein

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Cat: RP02667
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana E3 ubiquitin-protein ligase HOS1 (HOS1) , partial
Product Gene Name
HOS1 recombinant protein
Product Synonym Gene Name
HOS1
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
105,229 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
E3 ubiquitin-protein ligase

NCBI/Uniprot Data

NCBI Accession #
NP_181511.3
NCBI GI #
79571425
NCBI GenBank Nucleotide #
NM_129540.5
NCBI GeneID
818568
NCBI Official Full Name
ubiquitin-protein ligase
NCBI Official Symbol
HOS1
NCBI Official Synonym Symbols
EARLY IN SHORT DAYS 6; ESD6; HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 1; T5I7.11; T5I7_11
NCBI Protein Information
ubiquitin-protein ligase
NCBI Summary
A novel protein with a RING finger motif near the amino terminus. Negative regulator of cold responses. Functions as an E3 ligase required for the ubiquitination of ICE1. HOS1 physically interacts with ICE1 and mediates the ubiquitination of ICE1 both in vitro and in vivo. Overexpression represses the expression of CBFs and their downstream genes and confers increased sensitivity to freezing stress.
UniProt Gene Name
HOS1
UniProt Protein Name
E3 ubiquitin-protein ligase HOS1
UniProt Synonym Protein Names
Protein HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE 1; RING finger protein HOS1; RING-type E3 ubiquitin transferase HOS1Curated
UniProt Primary Accession #
Q84JU6
UniProt Secondary Accession #
O22289
UniProt Related Accession #
Q84JU6
UniProt Comments
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of the transcription factor ICE1. Acts as a negative regulator of cold signaling pathways (PubMed:16702557). Probably involved in recruiting the NUP107-160 subcomplex of the nuclear pore complex to chromatin (Probable). Controls flowering time in response to ambient temperatures (16 and 23 degrees Celsius) and intermittent cold, probably via the regulation of FT and TSF levels (PubMed:22960247).

For research use only, not for clinical use.