E3 ubiquitin-protein ligase CIP8 (CIP8), Recombinant Protein
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E3 ubiquitin-protein ligase CIP8 (CIP8), Recombinant Protein

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Cat: RP01684
Size: 0.02 mg (E-Coli)/ 0.02 mg (Yeast)/ 0.1 mg (E-Coli)/ 0.1 mg (Yeast)/ 0.02 mg (Baculovirus)/ 0.02 mg (Mammalian-Cell)/ 0.1 mg (Baculovirus)/ 1 mg (E-Coli)/ 1 mg (Yeast)/ 0.1 mg (Mammalian-Cell)/ 1 mg (Baculovirus)/ 0.5 mg (Mammalian-Cell)
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana E3 ubiquitin-protein ligase CIP8 (CIP8)
Product Gene Name
CIP8 recombinant protein
Product Synonym Gene Name
CIP8
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
MSDAPSSSPD ATASHWCYHC NKRVVVETLD DFVVCCECNK GFVESIQPTP AAYSSPAPPQ PLSPDLNVED SSIGSHFLQM LRLLAHAPSQ RSPPRHLDVL SYEDDFFRLE LNSRNEIDDD EDEDEDDGDE EEEDEEENLT VNDEEDEEDD LRRRNRFPLT TTQSRTGRNR ILDWAEILMG IEDNSIEFRM ESDRYAGNPA DYIDDAAGYE ALLQNLAEGD GGGGGGRRGA PPAAKSAIEA LETFEVSSSE GEMVMVCAVC KDGMVMGETG KKLPCGHCYH GDCIVPWLGT RNSCPVCRFQ LETDDAEYEE ERKKRTSTVS DSAAASSSSS TSRY
Sequence Positions
1-334, Full length protein
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
36,965 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
E3 ubiquitin-protein ligase

NCBI/Uniprot Data

NCBI Accession #
NP_201297.1
NCBI GI #
15238295
NCBI GenBank Nucleotide #
NM_125891.3
NCBI GeneID
836616
NCBI Official Full Name
COP1-interacting protein 8
NCBI Official Symbol
CIP8
NCBI Official Synonym Symbols
COP1-interacting protein 8; COP1-INTERACTING PROTEIN CIP8; MXK3.15; MXK3_15
NCBI Protein Information
COP1-interacting protein 8
NCBI Summary
Encodes a RING-H2 protein that interacts with the RING finger domain of COP1. CIP8 exhibits a strong interaction with the E2 ubiquitin conjugating enzyme AtUBC8 through its N-terminal domain and promotes ubiquitination in an E2-dependent fashion in vitro. It is possible that the AtUBC8-CIP8 module might interact with COP1 in vivo, thereby participating in proteasome-mediated degradation of HY5.
UniProt Gene Name
CIP8
UniProt Protein Name
E3 ubiquitin-protein ligase CIP8
UniProt Synonym Protein Names
COP1-interacting protein 8; RING-type E3 ubiquitin transferase CIP8Curated
UniProt Primary Accession #
Q9SPL2
UniProt Related Accession #
Q9SPL2
UniProt Comments
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. Probably forms a minimal ubiquitin ligase complex in cooperation with the E2 enzyme UBC8. Its interaction with COP1 suggests that it may participate in proteasome-mediated degradation of HY5 in vivo.

For research use only, not for clinical use.