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E3 ubiquitin-protein ligase BRE1-like 2 (HUB2), Recombinant Protein
Cat: RP02276
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana E3 ubiquitin-protein ligase BRE1-like 2 (HUB2) , partial
Product Gene Name
HUB2 recombinant protein
Product Synonym Gene Name
HUB2
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
44,251 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
E3 ubiquitin-protein ligase
NCBI/Uniprot Data
NCBI Accession #
NP_001154428.1
NCBI GI #
238478873
NCBI GenBank Nucleotide #
NM_001160956.1
NCBI GeneID
841968
NCBI Official Full Name
histone mono-ubiquitination 2
NCBI Official Symbol
HUB2
NCBI Official Synonym Symbols
F7A10.17; F7A10_17; histone mono-ubiquitination 2
NCBI Protein Information
histone mono-ubiquitination 2
NCBI Summary
Encodes one of two orthologous E3 ubiquitin ligases in Arabidopsis that are involved in monoubiquitination of histone H2B.
UniProt Gene Name
HUB2
UniProt Synonym Gene Names
BRE1B; AtHUB2
UniProt Protein Name
E3 ubiquitin-protein ligase BRE1-like 2
UniProt Synonym Protein Names
Protein HISTONE MONOUBIQUITINATION 2; AtHUB2; RING-type E3 ubiquitin transferase BRE1-like 2Curated
UniProt Primary Accession #
Q9C895
UniProt Secondary Accession #
Q058L1; Q8LDW7
UniProt Related Accession #
Q9C895
UniProt Comments
E3 ubiquitin-protein ligase that monoubiquitinates H2B to form H2BK143ub1. H2BK143ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and maybe H3K79me. It thereby plays a central role in histone code and gene regulation. Forms a ubiquitin ligase complex in cooperation with the E2 enzyme UBC2/RAD6.
For research use only, not for clinical use.