E3 ubiquitin ligase BIG BROTHER (BB), Recombinant Protein
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E3 ubiquitin ligase BIG BROTHER (BB), Recombinant Protein

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Cat: RP00068
Size: 0.02 mg (E-Coli)/ 0.1 mg (E-Coli)/ 0.02 mg (Yeast)/ 0.1 mg (Yeast)/ 0.02 mg (Baculovirus)/ 0.02 mg (Mammalian-Cell)/ 1 mg (E-Coli)/ 0.1 mg (Baculovirus)/ 1 mg (Yeast)/ 0.1 mg (Mammalian-Cell)/ 1 mg (Baculovirus)/ 0.5 mg (Mammalian-Cell)
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana E3 ubiquitin ligase BIG BROTHER (BB)
Product Gene Name
BB recombinant protein
Product Synonym Gene Name
BB
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
MNGDNRPVED AHYTETGFPY AATGSYMDFY GGAAQGPLNY DHAATMHPQD NLYWTMNTNA YKFGFSGSDN ASFYGSYDMN DHLSRMSIGR TNWDYHPMVN VADDPENTVA RSVQIGDTDE HSEAEECIAN EHDPDSPQVS WQDDIDPDTM TYEELVELGE AVGTESRGLS QELIETLPTK KYKFGSIFSR KRAGERCVIC QLKYKIGERQ MNLPCKHVYH SECISKWLSI NKVCPVCNSE VFGEPSIH
Sequence Positions
1-248, Full length protein
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
26,730 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
E3 ubiquitin ligase

NCBI/Uniprot Data

NCBI Accession #
NP_001030922.1
NCBI GI #
79316205
NCBI GenBank Nucleotide #
NM_001035845.2
NCBI GeneID
825528
NCBI Official Full Name
RING/U-box superfamily protein
NCBI Official Symbol
BB
NCBI Official Synonym Symbols
BB2; BIG BROTHER; ENHANCER1 OF DA1; EOD1
NCBI Protein Information
RING/U-box superfamily protein
NCBI Summary
Encodes a novel E3 ubiquitin ligase that acts as a central negative regulator of Arabidopsis floral organ size. Organ size is limited by restricting the period of proliferative growth, rather than the rate of growth and appears to act in a novel pathway, independent of ANT and JAG. Both mRNA and protein are expressed in all actively growing regions of the plant and the vasculature and the protein is rapidly turned over by proteasome-mediated degradation.
UniProt Gene Name
BB
UniProt Synonym Gene Names
EOD1
UniProt Protein Name
E3 ubiquitin ligase BIG BROTHER
UniProt Synonym Protein Names
Protein ENHANCER OF DA1-1; RING-type E3 ubiquitin transferase BIG BROTHERCurated
UniProt Primary Accession #
Q8L649
UniProt Secondary Accession #
C0Z296
UniProt Related Accession #
Q8L649
UniProt Comments
E3 ubiquitin-ligase that limits organ size, and possibly seed size, in a dose-dependent manner. Negatively regulates the duration of cell proliferation in leaves and petals independently of the major phytohormones (e.g. auxin, cytokinin, gibberellin, brassinosteroids, ethylene, abscisic acid, jasmonic acid), probably by targeting growth stimulators for degradation.

For research use only, not for clinical use.