Double-stranded RNA-binding protein 4 (DBR4), Recombinant Protein
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Double-stranded RNA-binding protein 4 (DBR4), Recombinant Protein

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Cat: RP02141
Size: 0.02 mg (E-Coli)/ 0.02 mg (Yeast)/ 0.1 mg (E-Coli)/ 0.1 mg (Yeast)/ 0.02 mg (Baculovirus)/ 0.02 mg (Mammalian-Cell)/ 0.1 mg (Baculovirus)/ 1 mg (E-Coli)/ 1 mg (Yeast)/ 0.1 mg (Mammalian-Cell)/ 1 mg (Baculovirus)/ 0.5 mg (Mammalian-Cell)
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana Double-stranded RNA-binding protein 4 (DBR4)
Product Gene Name
DBR4 recombinant protein
Product Synonym Gene Name
DBR4
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
MDHVYKGQLQ AYALQHNLEL PVYANEREGP PHAPRFRCNV TFCGQTFQSS EFFPTLKSAE HAAAKIAVAS LTPQSPEGID VAYKNLLQEI AQKESSLLPF YATATSGPSH APTFTSTVEF AGKVFSGEEA KTKKLAEMSA AKVAFMSIKN GNSNQTGSPT LPSERQEDVN SNVKSSPQEI HSQPSSKVVM TPDTPSKGIK VNEDEFPDLH DAPASNAKEI NVALNEPENP TNDGTLSALT TDGMKMNIAS SSLPIPHNPT NVITLNAPAA NGIKRNIAAC SSWMPQNPTN DGSETSSCVV DESEKKKLIM GTGHLSIPTG QHVVCRPWNP EITLPQDAEM LFRDDKFIAY RLVKP
Sequence Positions
1-355, Full length protein
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
35,716 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.

NCBI/Uniprot Data

NCBI Accession #
NP_001154686.1
NCBI GI #
238480134
NCBI GenBank Nucleotide #
NM_001161214.2
NCBI GeneID
825455
NCBI Official Full Name
double-stranded-RNA-binding protein 4
NCBI Official Symbol
DRB4
NCBI Official Synonym Symbols
ATTIF3K1; double-stranded-RNA-binding protein 4
NCBI Protein Information
double-stranded-RNA-binding protein 4
NCBI Summary
Encodes a nuclear dsRNA-binding protein DRB4 that interacts specifically with DCL4. May regulate DCL4 function and thereby affect miRNA biogenesis. Also has an impact on polymerase IV-dependent siRNA levels. DRB4 interacts with the P6 viral protein from Cauliflower mosaic virus and may be a target of viral silencing suppression.
UniProt Gene Name
DBR4
UniProt Synonym Gene Names
AtDRB4
UniProt Protein Name
Double-stranded RNA-binding protein 4
UniProt Synonym Protein Names
dsRNA-binding protein 4; AtDRB4
UniProt Primary Accession #
Q8H1D4
UniProt Secondary Accession #
Q8VXY2; Q9LZI5; B5BUY7
UniProt Related Accession #
Q8H1D4
UniProt Comments
Double-stranded RNA-binding protein involved in RNA-mediated post-transcriptional gene silencing (PTGS). Functions in the trans-acting small interfering RNAs (ta-siRNAs) biogenesis by binding and assisting DICER-LIKE 4 (DCL4). Required for DCL4 activity. Required for the 21 nucleotide ta-siRNAs production of the TAS3 transcript in leaves but not in flowers. Plays an important role in silencing RNA of both DNA and RNA viruses. Involved with argonaute 7 (AGO7) and RDR6 in turnip crinkle virus (TCV) silencing. May not be directly involved in viral siRNA production. May stabilize the 21 nucleotide viral siRNAs and deliver them to the RISC complex. Targeted by the viral silencing suppressor (VSR) transactivator/viroplasmin (TAV) protein of the cauliflower mosaic virus (CaMV) that inactivates DRB4 function in RNA silencing. Probably not involved in the guide strand selection from RNA duplexes. Involved in leaf morphology through its function in ta-siRNA-mediated silencing.

For research use only, not for clinical use.