Products
Online Inquiry
DNA repair protein REV1 (REV1), Recombinant Protein
Cat: RP02471
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana DNA repair protein REV1 (REV1) , partial
Product Gene Name
REV1 recombinant protein
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
49,003 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
DNA repair protein
NCBI/Uniprot Data
NCBI Accession #
NP_001119373.1
NCBI GI #
186529382
NCBI GenBank Nucleotide #
NM_001125901.2
NCBI GeneID
834504
NCBI Official Full Name
DNA-directed DNA polymerase
NCBI Official Symbol
REV1
NCBI Official Synonym Symbols
ARABIDOPSIS THALIANA HOMOLOG OF REVERSIONLESS 1; ATREV1; K23L20.9; K23L20_9
NCBI Protein Information
DNA-directed DNA polymerase
NCBI Summary
Homologous to Y-family DNA polymerases, contains BRCT domain. Mutants are sensitive to UV-B radiation. Gene is involved in damage-tolerance mechanisms through translesion synthesis(TLS).
UniProt Gene Name
REV1
UniProt Synonym Gene Names
AtREV1
UniProt Protein Name
DNA repair protein REV1
UniProt Synonym Protein Names
Rev1-like terminal deoxycytidyl transferase
UniProt Primary Accession #
A3EWL3
UniProt Secondary Accession #
O48585; Q5FBB9; Q8RXL1; A3EWL4; A3EWL5; A3EWL6; A3EWL7; A3EWL8
UniProt Related Accession #
A3EWL3
UniProt Comments
Deoxycytidyl transferase involved in DNA repair and translesion synthesis (TLS). Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. Mediates also the insertion of dTMP or dGMP when the opposite base is G, and, with a low efficiency, dGMP insertions opposite G, T, and C, dAMP insertions opposite G, A, and T, and dTMP insertion opposite A. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents (e.g. UV and gamma ray), mostly via G to T transversions, and of spontaneous mutations in somatic cells. Confers resistance to ultraviolet-B (UV-B) and various DNA cross-linkers (e.g. mitomycin C MMC and cisplatin). Promotes stem growth.
For research use only, not for clinical use.