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DNA ligase 1 (LIG1), Recombinant Protein
Cat: RP02449
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana DNA ligase 1 (LIG1) , partial
Product Gene Name
LIG1 recombinant protein
Product Synonym Gene Name
LIG1
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
81,167 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
DNA ligase
NCBI/Uniprot Data
NCBI Accession #
NP_172293.2
NCBI GI #
30680522
NCBI GenBank Nucleotide #
NM_100689.5
NCBI GeneID
837333
NCBI Official Full Name
DNA ligase 1
NCBI Official Symbol
LIG1
NCBI Official Synonym Symbols
ATLIG1; DNA ligase 1; T6D22.23
NCBI Protein Information
DNA ligase 1
NCBI Summary
Encodes the Arabidopsis DNA ligase 1 that provides the major DNA ligase activity in cells and plays a key role in both DNA replication and excision repair pathways. Indispensable for cell viability. AtLIG1 expresses one major and two minor mRNA transcripts differing only in the length of the 5' untranslated leader sequences preceding a common ORF. Translation from the first in-frame start codon produces an AtLIG1 isoform that is targeted exclusively to the mitochondria. Translation initiation from the second in-frame start codon produces an AtLIG1 isoform targeted only to the nucleus.
UniProt Gene Name
LIG1
UniProt Synonym Gene Names
AtLIG1
UniProt Protein Name
DNA ligase 1
UniProt Synonym Protein Names
DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1
UniProt Primary Accession #
Q42572
UniProt Secondary Accession #
Q541Y6; Q56W81; Q9LMZ4; Q9SGE5
UniProt Related Accession #
Q42572
UniProt Comments
Essential protein. DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Involved in repair of both single strand breaks (SSBs) and double strand breaks (DSBs). Required in the endosperm for embryogenesis, probably to repair DNA-breaks generated by DME.
For research use only, not for clinical use.