DNA excision repair protein ERCC-1 (ERCC1), Recombinant Protein
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DNA excision repair protein ERCC-1 (ERCC1), Recombinant Protein

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Cat: RP04515
Size: 0.02 mg (E-Coli)/ 0.02 mg (Yeast)/ 0.1 mg (E-Coli)/ 0.1 mg (Yeast)/ 0.02 mg (Baculovirus)/ 0.02 mg (Mammalian-Cell)/ 0.1 mg (Baculovirus)/ 1 mg (E-Coli)/ 1 mg (Yeast)/ 0.1 mg (Mammalian-Cell)/ 1 mg (Baculovirus)/ 0.5 mg (Mammalian-Cell)
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana DNA excision repair protein ERCC-1 (ERCC1)
Product Gene Name
ERCC1 recombinant protein
Product Synonym Gene Name
ERCC1
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
MANEDDDGEK SRSLHQQIAR KPKTQIVIGV PSYQEVLESS QTKSTPPSLF KPSQSFSQAF AFVKSSDVYS PPPPSSAAAS SSQPSGASQV PHSSSQTHQT DGASSSSTPV ATGSVPSNTT QNRNAILVSH RQKGNPLLKH IRNVKWVFSD IIPDYVLGQN SCALYLSLRY HLLHPDYLYF RIRELQKNFK LSVVLCHVDV EDTVKPLLEV TKTALLHDCT LLCAWSMTEC ARYLETIKVY ENKPADLIQG QMDTDYLSRL NHSLTSIRHV NKSDVVTLGS TFGSLAHIID ASMEDLARCP GIGERKVKRL YDTFHEPFKR ATSSYPSVVE PPIPEAPVEK DVNSEEPVEE DEDFVEDSRK RKKKEPEPEK TVKTALSAVF ARYSDRLSKK KEKQKEKDTT TASDAETHQN
Sequence Positions
1-410, Full length protein
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
45,748 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
DNA excision repair protein

NCBI/Uniprot Data

NCBI Accession #
NP_187172.1
NCBI GI #
15229933
NCBI GenBank Nucleotide #
NM_111394.5
NCBI GeneID
819685
NCBI Official Full Name
nucleotide repair protein
NCBI Official Symbol
ERCC1
NCBI Official Synonym Symbols
T12H1.18; T12H1_18; UV REPAIR DEFICIENT 7; UVR7
NCBI Protein Information
nucleotide repair protein
NCBI Summary
encodes a homolog of human ERCC1 protein (yeast RAD10), which is a DNA repair endonuclease. Mutants are sensitive to UV-B and gamma radiation (G2 cell cycle phase arrest) and are defective in dark-repair of pyrimidine pyrimidone dimers. This protein incises the 5' end of damaged DNA, similar to ERCC1/RAD10.
UniProt Gene Name
ERCC1
UniProt Synonym Gene Names
RAD10; UVR7; AtERCC1; AtRAD10
UniProt Protein Name
DNA excision repair protein ERCC-1
UniProt Synonym Protein Names
Ultraviolet hypersensitive 7
UniProt Primary Accession #
Q9MA98
UniProt Related Accession #
Q9MA98
UniProt Comments
Seems to be involved in nucleotide excision repair (NER) of damaged DNA (dark repair mechanism). The UVH1/RAD1-ERCC1/RAD10 complex may act as an endonuclease making DNA incision 5' to the lesion site. In vitro, is implicated in double strand breaks (DSBs) repair and is required for homologous recombination in the presence of non-homologous overhangs. In vitro, is involved in chromosomal recombination between tandem repeats in both direct and inverted orientations. May mediate the induction of a DNA-damage sensitive cell-cycle checkpoint during the G2 phase.

For research use only, not for clinical use.