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DNA-directed RNA polymerase D subunit 1 (NRPD1), Recombinant Protein
Cat: RP04122
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana DNA-directed RNA polymerase D subunit 1 (NRPD1) , partial
Product Gene Name
NRPD1 recombinant protein
Product Synonym Gene Name
NRPD1
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
162,521 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
DNA-directed RNA polymerase
NCBI/Uniprot Data
NCBI Accession #
NP_001185298.1
NCBI GI #
334183598
NCBI GenBank Nucleotide #
NM_001198369.1
NCBI GeneID
842605
NCBI Official Full Name
nuclear RNA polymerase D1A
NCBI Official Symbol
NRPD1A
NCBI Official Synonym Symbols
F16P17.19; F16P17_19; NRPD1; NUCLEAR RNA POLYMERASE D 1A; nuclear RNA polymerase D1A; POL IVA; SDE4; SILENCING MOVEMENT DEFICIENT 2; SMD2
NCBI Protein Information
nuclear RNA polymerase D1A
NCBI Summary
Encodes one of two alternative largest subunits of a putative plant-specific RNA polymerase IV (aka RNA polymerase D). Required for posttranscriptional gene silencing.
UniProt Gene Name
NRPD1
UniProt Synonym Gene Names
NRPD1a; RMD3; RPD1; SDE4; SMD2; AtNRPD1a; Nuclear RNA polymerase D 1a; POL IV 1a
UniProt Protein Name
DNA-directed RNA polymerase IV subunit 1
UniProt Synonym Protein Names
DNA-directed RNA polymerase D subunit 1 (EC:2.7.7.6); AtNRPD1a; Nuclear RNA polymerase D 1a; Protein RNA-DIRECTED DNA METHYLATION DEFECTIVE 3; Protein SILENCING DEFECTIVE 4; Protein SILENCING MOVEMENT DEFICIENT 2; RNA polymerase IV subunit 1a; POL IV 1a
UniProt Primary Accession #
Q9LQ02
UniProt Related Accession #
Q9LQ02
UniProt Comments
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates . Largest and catalytic component of RNA polymerase IV which mediates 24-nt short-interfering RNAs (siRNA) accumulation. Implicated in siRNA-directed heterochromatin formation through the action of DCL3 and AGO4, and subsequent DNA methylation-dependent silencing of targeted sequences. Essential component of a self-reinforcing loop coupling de novo DNA methylation to siRNA production. Required for intercellular but not intracellular RNA interference (RNAi) leading to systemic post-transcriptional gene silencing. Involved in the maintenance of post-transcriptional RNA silencing.
For research use only, not for clinical use.