NCBI Accession #
NP_567719.1
NCBI GenBank Nucleotide #
NM_118679.2
NCBI Official Full Name
C-repeat/DRE binding factor 2
NCBI Official Symbol
CBF2
NCBI Official Synonym Symbols
ATCBF2; C-repeat/DRE binding factor 2; DRE/CRT-BINDING PROTEIN; DRE/CRT-BINDING PROTEIN 1C; DREB1C; FREEZING TOLERANCE QTL 4; FTQ4; T30C3.12
NCBI Protein Information
C-repeat/DRE binding factor 2
NCBI Summary
Encodes a member of the DREB subfamily A-1 of ERF/AP2 transcription factor family (CBF2). The protein contains one AP2 domain. There are six members in this subfamily, including CBF1, CBF2, and CBF3. This gene is involved in response to low temperature, abscisic acid, and circadian rhythm. Overexpressing this gene leads to increased freeze tolerance and induces the expression level of 85 cold-induced genes and reduces the expression level of 8 cold-repressed genes, which constitute the CBF2 regulon. Mutations in CBF2 increases the expression level of CBF1 and CBF3, suggesting that this gene may be involved in a negative regulatory or feedback circuit of the CBF pathway.
UniProt Synonym Gene Names
CBF2; ERF030; Protein DREB1C; C-repeat-binding factor 2; CRT/DRE-binding factor 2
UniProt Protein Name
Dehydration-responsive element-binding protein 1C
UniProt Synonym Protein Names
C-repeat/dehydration-responsive element-binding factor 2; C-repeat-binding factor 2; CRT/DRE-binding factor 2
UniProt Primary Accession #
Q9SYS6
UniProt Secondary Accession #
O65613; O82776; Q08A88; Q5QE69
UniProt Related Accession #
Q9SYS6
UniProt Comments
Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'. Binding to the C-repeat/DRE element mediates cold-inducible transcription. CBF/DREB1 factors play a key role in freezing tolerance and cold acclimation.