NCBI Accession #
NP_564497.1
NCBI GenBank Nucleotide #
NM_103612.3
NCBI Official Full Name
Granulin repeat cysteine protease family protein
NCBI Official Symbol
RD21A
NCBI Official Synonym Symbols
F2G19.31; F2G19_31; RD21; responsive to dehydration 21; responsive to dehydration 21A; RESPONSIVE TO DEHYDRATION 21A
NCBI Protein Information
Granulin repeat cysteine protease family protein
NCBI Summary
cysteine proteinase precursor-like protein/ dehydration stress-responsive gene (RD21). Has been shown to have peptide ligase activity and protease activity in vitro. RD21 is involved in immunity to the necrotrophic fungal pathogen Botrytis cinerea.
UniProt Synonym Gene Names
RD21
UniProt Protein Name
Cysteine proteinase RD21A
UniProt Synonym Protein Names
Protein RESPONSIVE TO DEHYDRATION 21
UniProt Primary Accession #
P43297
UniProt Related Accession #
P43297
UniProt Comments
Cysteine protease that plays a role in immunity, senescence, and biotic and abiotic stresses (Probable). Involved in immunity against the necrotrophic fungal pathogen Botrytis cinerea (PubMed:22238602). Involved in elicitor-stimulated programmed cell death (PCD). During infection by the necrotrophic fungal pathogen Botrytis cinerea, functions as PCD-promoting protease that is released from the ER body or vacuole to the cytoplasm (PubMed:23398119). Accumulates in endoplasmic reticulum-derived bodies in epidermal cells and may participate in cell death in stressed or injured cells (PubMed:11577182). Involved in water stress-induced cell death through its protease activity that is released to the cytoplasm after vacuolar collapse (PubMed:26884487). Possesses protease activity in vitro and is involved in cell death in the transmitting tract and septum epidermis during flower development (PubMed:26160583). Possesses peptide ligase activity. Can ligate peptides to unmodified N-termini of acceptor proteins. Probably ligates through a thioester intermediate (PubMed:18660805).