Cyclic nucleotide-gated ion channel 2 (CNGC2), Recombinant Protein
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Cyclic nucleotide-gated ion channel 2 (CNGC2), Recombinant Protein

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Cat: RP06333
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana Cyclic nucleotide-gated ion channel 2 (CNGC2) , partial
Product Gene Name
CNGC2 recombinant protein
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
83,241 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Cyclic nucleotide-gated ion channel

NCBI/Uniprot Data

NCBI Accession #
NP_197045.1
NCBI GI #
15242291
NCBI GenBank Nucleotide #
NM_121545.5
NCBI GeneID
831393
NCBI Official Full Name
Cyclic nucleotide-regulated ion channel family protein
NCBI Official Symbol
DND1
NCBI Official Synonym Symbols
ATCNGC2; CNGC2; CYCLIC NUCLEOTIDE GATED CHANNEL 2; CYCLIC NUCLEOTIDE-GATED CHANNEL 2; DEFENSE NO DEATH 1
NCBI Protein Information
Cyclic nucleotide-regulated ion channel family protein
NCBI Summary
'defense, no death' gene (DND1) encodes a mutated cyclic nucleotide-gated cation channel; Same as CNGC2 (article ID 229): Cyclic nucleotide gated channel, activated by cAMP, conducts K+ and other monovalent cations but excludes Na+, does not contain the GYG amino acid sequence found in other channels with this conductivity profile. Conducts Ca2+ into cells which is linked to the generation of NO and the NO signaling pathway involved in the innate immune response to pathogens.
UniProt Gene Name
CNGC2
UniProt Synonym Gene Names
DND1; AtCNGC2
UniProt Protein Name
Cyclic nucleotide-gated ion channel 2
UniProt Synonym Protein Names
Cyclic nucleotide- and calmodulin-regulated ion channel 2; Protein DEFENSE NO DEATH 1
UniProt Primary Accession #
O65718
UniProt Related Accession #
O65718
UniProt Comments
Acts as cyclic nucleotide-gated ion channel. Permeable to potassium and calcium in a cyclic nucleotide-dependent fashion (cAMP or cGMP). Could also transport lithium, cesium and rubium and displays a strong selectivity against sodium. Seems to directly participate in pathogen-induced calcium influx. May function in homeostasis, re-establishing ionic balance after defense action and/or other stimuli. Could mediate the initiation of the developmentally regulated cell death programs.

For research use only, not for clinical use.