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Cullin-associated NEDD8-dissociated protein 1 (CAND1), Recombinant Protein
Cat: RP05094
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Cullin-associated NEDD8-dissociated protein 1 (CAND1) , partial
Product Gene Name
CAND1 recombinant protein
Product Synonym Gene Name
CAND1
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
134,622 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
NCBI/Uniprot Data
NCBI Accession #
NP_001030954.1
NCBI GI #
79316548
NCBI GenBank Nucleotide #
NM_001035877.2
NCBI GeneID
814786
NCBI Official Full Name
cullin-associated and neddylation dissociated
NCBI Official Symbol
CAND1
NCBI Official Synonym Symbols
ATCAND1; cullin-associated and neddylation dissociated; CULLIN-ASSOCIATED AND NEDDYLATION DISSOCIATED 1; ETA2; HEMIVENATA; HVE; T8K22.14; T8K22_14; TIP120
NCBI Protein Information
cullin-associated and neddylation dissociated
NCBI Summary
Arabidopsis thaliana homolog of human CAND1 (cullin-associated and neddylation-dissociated). Putative similarity to TBP-interacting protein TIP120. Ubiquitously expressed in plant tissues throughout development. T-DNA insertion mutant plants were completely sterile and resistant to sirtinol and auxin, but not to gibberellins or brassinolide. Displayed developmental phenotypes similar to those of axr1, namely, short petioles, downwardly curling leaves, shorter inflorescence. Required for SCF function and appears to modulate SCF complex cycling. Physically interacts with CUL1.
UniProt Gene Name
CAND1
UniProt Synonym Gene Names
ETA2; HVE; AtCAND1
UniProt Protein Name
Cullin-associated NEDD8-dissociated protein 1
UniProt Synonym Protein Names
Cullin-associated and neddylation-dissociated protein 1; AtCAND1; Protein ENHANCER OF TIR1-1 AUXIN RESISTANCE 2; Protein HEMIVENATA
UniProt Primary Accession #
Q8L5Y6
UniProt Secondary Accession #
O64720
UniProt Related Accession #
Q8L5Y6
UniProt Comments
Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor . Required for SCF(TIR1) function. Modulates SCF(TIR1) function through its interactions with the CUL1 subunit. Represses photomorphogenesis by promoting HY5 degradation in darkness.
For research use only, not for clinical use.