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CSN4, Recombinant Protein
Cat: RP03738
Size: 0.05 mg/ 0.1 mg/ 5x0.1 mg
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Mouse-ear cress CSN4 protein, N-His Tag
Product Synonym Names
COP8; FUS4
Product Gene Name
CSN4 recombinant protein
Purity
>90% as determined by SDS-PAGE
Format
Lyophilized. Lyophilized from PBS PH 7.4, 4M Urea, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.
Host
E Coli
Molecular Weight
44,957 Da
Storage
Store at 2 to 8℃ for one week. Store at -20 to -80℃ for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Protein Family
COP9 signalosome complex
NCBI/Uniprot Data
NCBI Accession #
NP_199111.1
NCBI GI #
15239134
NCBI GenBank Nucleotide #
NM_123663.3
NCBI GeneID
834312
NCBI Official Full Name
Proteasome component (PCI) domain protein
NCBI Official Symbol
COP8
NCBI Official Synonym Symbols
ATS4; CONSTITUTIVE PHOTOMORPHOGENIC 14; CONSTITUTIVE PHOTOMORPHOGENIC 8; COP14; COP9 SIGNALOSOME SUBUNIT 4; CSN4; EMB134; EMBRYO DEFECTIVE 134; FUS4; FUS8; FUSCA 4; FUSCA 8; MBD2.17; MBD2_17
NCBI Protein Information
Proteasome component (PCI) domain protein
NCBI Summary
encodes subunit 4 of COP9 signalosome complex. sequence is similar to a subunit of the 19S regulatory particle of the 26S proteasome. recessive mutation causes derepression of photomorphogenesis.
UniProt Gene Name
CSN4
UniProt Synonym Gene Names
COP8; FUS4; AtS4; Signalosome subunit 4
UniProt Protein Name
COP9 signalosome complex subunit 4
UniProt Synonym Protein Names
Constitutive photomorphogenesis protein 8; Protein FUSCA 4
UniProt Primary Accession #
Q8L5U0
UniProt Secondary Accession #
Q9FMM1; Q9SW74
UniProt Related Accession #
Q8L5U0
UniProt Comments
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of IAA6 by regulating the activity of the Ubl ligase SCF-TIR complex.
For research use only, not for clinical use.