NCBI Accession #
NP_563645.1
NCBI GenBank Nucleotide #
NM_100089.3
NCBI Official Full Name
Proteasome component (PCI) domain protein
NCBI Official Symbol
FUS5
NCBI Official Synonym Symbols
ARABIDOPSIS THALIANA COP9 SIGNALOSOME SUBUNIT 7; ATCSN7; CONSTITUTIVE PHOTOMORPHOGENIC 15; COP15; COP9 SIGNALOSOME SUBUNIT 7; CSN7; FUSCA 5; T7I23.25; T7I23_25
NCBI Protein Information
Proteasome component (PCI) domain protein
NCBI Summary
encodes a phosphoprotein that is a subunit of the COP9 signalosome. Mutants exhibit constitutive photomorphogenic phenotype.
UniProt Synonym Gene Names
FUS5; CSN complex subunit 7
UniProt Protein Name
COP9 signalosome complex subunit 7
UniProt Synonym Protein Names
Protein FUSCA 5
UniProt Primary Accession #
Q94JU3
UniProt Secondary Accession #
O81247
UniProt Related Accession #
Q94JU3
UniProt Comments
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of IAA6 by regulating the activity of the Ubl ligase SCF-TIR complex. Regulates the TSO2 subcellular localization. May be involved in nucleic acid binding.