NCBI Accession #
NP_567746.1
NCBI GenBank Nucleotide #
NM_118776.3
NCBI Official Full Name
COP9 signalosome subunit 6B
NCBI Official Symbol
CSN6B
NCBI Official Synonym Symbols
COP9 signalosome subunit 6B; M3E9.140; M3E9_140
NCBI Protein Information
COP9 signalosome subunit 6B
NCBI Summary
one of two genes encoding subunit 6 of COP9 signalosome complex
UniProt Synonym Gene Names
Signalosome subunit 6b
UniProt Protein Name
COP9 signalosome complex subunit 6b
UniProt Primary Accession #
Q8W1P0
UniProt Secondary Accession #
O65591; Q8RXW5; Q8W205
UniProt Related Accession #
Q8W1P0
UniProt Comments
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of PSIAA6 by regulating the activity of the Ubl ligase SCF-TIR complex. Essential for the structural integrity of the CSN holocomplex (PubMed:17307927).