COP9 signalosome complex subunit 6a (CSN6A), Recombinant Protein
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COP9 signalosome complex subunit 6a (CSN6A), Recombinant Protein

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Cat: RP05616
Size: 0.02 mg (E-Coli)/ 0.02 mg (Yeast)/ 0.1 mg (E-Coli)/ 0.1 mg (Yeast)/ 0.02 mg (Baculovirus)/ 0.02 mg (Mammalian-Cell)/ 0.1 mg (Baculovirus)/ 1 mg (E-Coli)/ 1 mg (Yeast)/ 0.1 mg (Mammalian-Cell)/ 1 mg (Baculovirus)/ 0.5 mg (Mammalian-Cell)
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana COP9 signalosome complex subunit 6a (CSN6A)
Product Gene Name
CSN6A recombinant protein
Product Synonym Gene Name
CSN6A
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
MAPSSSSGLT FKLHPLVIVN ISDHYTRVKT QLNPPASICA SGHGSNNGEA MFQQNPRVYG CVIGVQRGRT VEIFNSFELL YDPSTQTLDR SFLEKKQELY KKVFPDFYIL GWYSTGSDAE ESDMHIHKAL MDINESPVYV LLNPAINHTQ KDLPVTIYES ELHVIDGIPQ LIFAHTSYTI ETVEAERISV DHVAHLKPSD GGSAATQLAA HLTGIHSAIK MLNSRIRVLY QNLAAMQKGD KSCDNSVLRQ VSSLLRRLPA MESERFQDNF LMEYNDKLLI TYLAMITNCS SNMNEMVDKF NTAYDRNTRR GGRTAFM
Sequence Positions
1-317, Full length protein
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
35,659 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
COP9 signalosome complex

NCBI/Uniprot Data

NCBI Accession #
NP_568839.1
NCBI GI #
18423847
NCBI GenBank Nucleotide #
NM_125011.4
NCBI GeneID
835727
NCBI Official Full Name
COP9 signalosome subunit 6A
NCBI Official Symbol
CSN6A
NCBI Official Synonym Symbols
COP9 signalosome subunit 6A; MXK23.2; MXK23_2
NCBI Protein Information
COP9 signalosome subunit 6A
NCBI Summary
one of two genes encoding subunit 6 of COP9 signalosome complex. Protein contains a MPR1p and PAD1p N-terminal (MPN) domain at the N-terminal region and belongs to the Mov34 superfamily. Mutant and antisense expression result in a number of developmental defects and in ubiquitin/proteasome-mediated protein degradation.
UniProt Gene Name
CSN6A
UniProt Synonym Gene Names
Signalosome subunit 6a
UniProt Protein Name
COP9 signalosome complex subunit 6a
UniProt Primary Accession #
Q8W206
UniProt Secondary Accession #
Q84WB5; Q941I1; Q9FG76
UniProt Related Accession #
Q8W206
UniProt Comments
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of PSIAA6 by regulating the activity of the Ubl ligase SCF-TIR complex. Essential for the structural integrity of the CSN holocomplex (PubMed:17307927).

For research use only, not for clinical use.