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COP9 signalosome complex subunit 5a (CSN5A), Recombinant Protein
Cat: RP04323
Size: 0.02 mg (E-Coli)/ 0.02 mg (Yeast)/ 0.1 mg (E-Coli)/ 0.1 mg (Yeast)/ 0.02 mg (Baculovirus)/ 0.02 mg (Mammalian-Cell)/ 0.1 mg (Baculovirus)/ 1 mg (E-Coli)/ 1 mg (Yeast)/ 0.1 mg (Mammalian-Cell)/ 1 mg (Baculovirus)/ 0.5 mg (Mammalian-Cell)
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana COP9 signalosome complex subunit 5a (CSN5A)
Product Gene Name
CSN5A recombinant protein
Product Synonym Gene Name
CSN5A
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
MEGSSSTIAR KTWELENSIL TVDSPDSTSD NIFYYDDTSQ TRFQQEKPWE NDPHYFKRVK ISALALLKMV VHARSGGTIE IMGLMQGKTD GDTIIVMDAF ALPVEGTETR VNAQDDAYEY MVEYSQTNKL AGRLENVVGW YHSHPGYGCW LSGIDVSTQR LNQQHQEPFL AVVIDPTRTV SAGKVEIGAF RTYSKGYKPP DEPVSEYQTI PLNKIEDFGV HCKQYYSLDV TYFKSSLDSH LLDLLWNKYW VNTLSSSPLL GNGDYVAGQI SDLAEKLEQA ESHLVQSRFG GVVPSSLHKK KEDESQLTKI TRDSAKITVE QVHGLMSQVI KDELFNSMRQ SNNKSPTDSS DPDPMITY
Sequence Positions
1-358, Full length protein
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
40,318 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
COP9 signalosome complex
NCBI/Uniprot Data
NCBI Accession #
NP_177279.1
NCBI GI #
15224003
NCBI GenBank Nucleotide #
NM_105792.2
NCBI GeneID
843463
NCBI Official Full Name
COP9-signalosome 5B
NCBI Official Symbol
CSN5B
NCBI Official Synonym Symbols
AJH2; COP9-signalosome 5B; CSN5; F3I17.12; F3I17_12
NCBI Protein Information
COP9-signalosome 5B
NCBI Summary
Encodes a subunit of the COP9 complex, similar to JAB1, a specific mammalian coactivator of AP-1 transcription. Involved in protein deneddylation. Double mutants with CSN5A are constitutively photomorphogenic (de-etiolated) and have abnormal auxin responses.
UniProt Gene Name
CSN5B
UniProt Synonym Gene Names
Signalosome subunit 5b
UniProt Protein Name
COP9 signalosome complex subunit 5b
UniProt Synonym Protein Names
Jun activation domain-binding homolog 2
UniProt Primary Accession #
Q9FVU9
UniProt Secondary Accession #
O82523
UniProt Related Accession #
Q9FVU9
UniProt Comments
Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex . The CSN complex is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of PSIAA6 by regulating the activity of the Ubl ligase SCF-TIR complex. Not involved in CSN's deneddylation/derubylation activity (PubMed:15486099, PubMed:17307927). Essential for the structural integrity of the CSN holocomplex (PubMed:17307927).
For research use only, not for clinical use.