NCBI Accession #
NP_568296.1
NCBI GenBank Nucleotide #
NM_121429.5
NCBI Official Full Name
Proteasome component (PCI) domain protein
NCBI Official Symbol
COP13
NCBI Official Synonym Symbols
CONSTITUTIVE PHOTOMORPHOGENIC 13; COP9 SIGNALOSOME SUBUNIT 3; CSN3; F18O22.40; F18O22_40; FUS11; FUSCA 11
NCBI Protein Information
Proteasome component (PCI) domain protein
NCBI Summary
Encodes subunit 3 of the COP9 signalosome.
UniProt Synonym Gene Names
FUS11; Signalosome subunit 3
UniProt Protein Name
COP9 signalosome complex subunit 3
UniProt Synonym Protein Names
Protein FUSCA 11
UniProt Primary Accession #
Q8W575
UniProt Secondary Accession #
Q93VY1; Q9LYA4
UniProt Related Accession #
Q8W575
UniProt Comments
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of IAA6 by regulating the activity of the Ubl ligase SCF-TIR complex.