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Chromo domain-containing protein LHP1 (LHP1), Recombinant Protein
Cat: RP02388
Size: 0.02 mg (E-Coli)/ 0.02 mg (Yeast)/ 0.1 mg (E-Coli)/ 0.1 mg (Yeast)/ 0.02 mg (Baculovirus)/ 0.02 mg (Mammalian-Cell)/ 0.1 mg (Baculovirus)/ 1 mg (E-Coli)/ 0.1 mg (Mammalian-Cell)/ 1 mg (Yeast)/ 1 mg (Baculovirus)/ 0.5 mg (Mammalian-Cell)
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Chromo domain-containing protein LHP1 (LHP1)
Product Gene Name
LHP1 recombinant protein
Product Synonym Gene Name
LHP1
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
MKGASGAVKK KPQVLNEAGE AETAVETVGE SRKISGDGGF GSDDGGGGGG GGSGESILRE IGDDRPTEDG DEEEEEDEDE DDGGDEEDEE GEGEGGQEER PKLDEGFYEI EAIRRKRVRK GKVQYLIKWR GWPETANTWE PLENLQSIAD VIDAFEGSLK PGKPGRKRKR KYAGPHSQMK KKQRLTSTSH DATEKSDSST SLNNSSLPDI PDPLDLSGSS LLNRDVEAKN AYVSNQVEAN SGSVGMARQV RLIDNEKEYD PTLNELRGPV NNSNGAGCSQ GGGIGSEGDN VRPNGLLKVY PKELDKNSRF IGAKRRKSGS VKRFKQDGST SNNHTAPTDQ NLTPDLTTLD SFGRIARMGN EYPGVMENCN LSQKTKIEEL DITKILKPMS FTASVSDNVQ EVLVTFLALR SDGKEALVDN RFLKAHNPHL LIEFYEQHLK YNRTP
Sequence Positions
1-445, Full length protein
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
48,644 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Chromo domain protein
NCBI/Uniprot Data
NCBI Accession #
NP_197271.1
NCBI GI #
15238009
NCBI GenBank Nucleotide #
NM_121775.3
NCBI GeneID
831635
NCBI Official Full Name
like heterochromatin protein (LHP1)
NCBI Official Symbol
TFL2
NCBI Official Synonym Symbols
AtLHP1; LHP1; LIKE HETEROCHROMATIN PROTEIN 1; MVA3.4; MVA3_4; TERMINAL FLOWER 2
NCBI Protein Information
like heterochromatin protein (LHP1)
NCBI Summary
Regulates the meristem response to light signals and the maintenance of inflorescence meristem identity. Influences developmental processes controlled by APETALA1. TFL2 silences specific genes within euchromatin but not genes positioned in heterochromatin. TFL2 protein localized preferentially to euchromatic regions and not to heterochromatic chromocenters. Involved in euchromatin organization. Required for epigenetic maintenance of the vernalized state.
UniProt Gene Name
LHP1
UniProt Synonym Gene Names
TFL2; TU8
UniProt Protein Name
Chromo domain-containing protein LHP1
UniProt Synonym Protein Names
Protein LIKE HETEROCHROMATIN PROTEIN 1; Protein TERMINAL FLOWER 2
UniProt Primary Accession #
Q946J8
UniProt Secondary Accession #
Q9FN82
UniProt Related Accession #
Q946J8
UniProt Comments
Structural component of heterochromatin involved in gene repression, including several floral homeotic genes and FLT that regulates flowering time. Required for maintenance of vernalization-induced repression of FLC. As part of the PRC1-like complex, recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me), leading to epigenetic repression. PcG PRC1 complex maintains the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Transcriptional repressor that binds DNA on GAGA-like motif and 5'-(A/G/T)AACCCTA(A/G)-3' consensus motif in the promoters of target genes. Recognizes and binds histone H3 tails methylated at 'Lys-27' (H3K27me) but depleted in active histone marks such as H3K4me, leading to epigenetic repression. When in complex with LHP1, recognizes and binds histone H3 tails methylated at 'Lys-4' (H3K4me) and 'Lys-27' (H3K27me), mostly corresponding to stress-responsive genes (PubMed:27495811).
For research use only, not for clinical use.