NCBI Accession #
NP_194825.1
NCBI GenBank Nucleotide #
NM_119244.3
NCBI Official Full Name
SOS3-interacting protein 3
NCBI Official Symbol
SIP3
NCBI Official Synonym Symbols
ATCIPK6; CBL-INTERACTING PROTEIN KINASE 6; CIPK6; F6I18.130; F6I18_130; SNF1-RELATED PROTEIN KINASE 3.14; SNRK3.14; SOS3-interacting protein 3
NCBI Protein Information
SOS3-interacting protein 3
NCBI Summary
Encodes CBL-interacting protein kinase 6 (CIPK6). Required for development and salt tolerance.
UniProt Synonym Gene Names
PKS4; SIP3; SnRK3.14
UniProt Protein Name
CBL-interacting serine/threonine-protein kinase 6
UniProt Synonym Protein Names
SNF1-related kinase 3.14; SOS2-like protein kinase PKS4; SOS3-interacting protein 3
UniProt Primary Accession #
O65554
UniProt Related Accession #
O65554
UniProt Comments
CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner. Downstream of CBL1, CBL2, CBL3 and CBL9, regulates by phosphorylation the K+ conductance and uptake of AKT1. Binds to CBL4 to modulate AKT2 activity by promoting a kinase interaction-dependent but phosphorylation-independent translocation of the channel to the plasma membrane.