NCBI Accession #
NP_174998.1
NCBI GenBank Nucleotide #
NM_103458.3
NCBI Official Full Name
basic region/leucine zipper motif 60
NCBI Official Symbol
BZIP60
NCBI Official Synonym Symbols
ATBZIP60; basic region/leucine zipper motif 60; Bbasic region/leucine zipper motif 60; F13A11.5; F13A11_5
NCBI Protein Information
basic region/leucine zipper motif 60
NCBI Summary
bZIP60 consists of a bZIP DNA binding domain followed by a putative transmembrane domain. bZIP60 mRNA is upregulated by the addition of ER stress inducers, tunicamycin (inhibitor of N-linked glycosylation), DTT (inhibitor of disulfide bond formation) and azetin-2-carboxylate (proline analog perturbing protein structure). Upon ER stress, bZIP60 mRNA is spliced by IRE1A and IRE1B to produce bZIP60-S, an active transcription factor without the transmembrane domain. bZIP60-U, a product of unspliced form of bZIP60 mRNA, is localized at the ER membrane and bZIP60-S is localized in the nucleus.
UniProt Synonym Gene Names
AtbZIP60
UniProt Protein Name
bZIP transcription factor 60
UniProt Primary Accession #
Q9C7S0
UniProt Related Accession #
Q9C7S0
UniProt Comments
Transcription factor involved in the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Plays a role in plant immunity and abiotic stress responses.