NCBI Accession #
NP_565882.1
NCBI GenBank Nucleotide #
NM_129368.3
NCBI Official Full Name
Transmembrane amino acid transporter family protein
NCBI Official Symbol
AUX1
NCBI Official Synonym Symbols
AtAUX1; AUXIN RESISTANT 1; F16M14.5; F16M14_5; MAP1; MODIFIER OF ARF7/NPH4 PHENOTYPES 1; PIR1; WAV5; WAVY ROOTS 5
NCBI Protein Information
Transmembrane amino acid transporter family protein
NCBI Summary
Encodes an auxin influx transporter. AUX1 resides at the apical plasma membrane of protophloem cells and at highly dynamic subpopulations of Golgi apparatus and endosomes in all cell types. AUX1 action in the lateral root cap and/or epidermal cells influences lateral root initiation and positioning. Shoot supplied ammonium targets AUX1 and inhibits lateral root emergence.
UniProt Synonym Gene Names
AUX; PIR1; WAV5
UniProt Protein Name
Auxin transporter protein 1
UniProt Synonym Protein Names
Auxin influx carrier protein 1; Polar auxin transport inhibitor-resistant protein 1
UniProt Primary Accession #
Q96247
UniProt Related Accession #
Q96247
UniProt Comments
Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex. Unloads auxin from the mature phloem to deliver the hormone to the root meristem via the protophloem cell files. Coordinated subcellular localization of AUX1 is regulated by a brefeldin A-sensitive (BFA) vesicle trafficking process. Involved in lateral root formation, trichoblast polarization and root hair elongation. Required for gravitropism and thigmotropism, especially in roots, by modulating responses to auxin, ethylene and cytokinins such as benzyladenine (BA). Needed for ammonium-mediated root-growth inhibition. Confers sensitivity to the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D, auxin analog), and to polar auxin transport inhibitors such as N-1-naphthylphthalamic acid (NPA) and 2,3,5-triiodobenzoic acid (TIBA).