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ATP-dependent DNA helicase Q-like 4A (RECQL4A), Recombinant Protein
Cat: RP08258
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana ATP-dependent DNA helicase Q-like 4A (RECQL4A) , partial
Product Gene Name
RECQL4A recombinant protein
Product Synonym Gene Name
RECQL4A
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
133,312 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
ATP-dependent DNA helicase
NCBI/Uniprot Data
NCBI Accession #
NP_172562.2
NCBI GI #
30681987
NCBI GenBank Nucleotide #
NM_100968.3
NCBI GeneID
837636
NCBI Official Full Name
DNA helicase (RECQl4A)
NCBI Official Symbol
RECQ4A
NCBI Official Synonym Symbols
ATRECQ4A; ATSGS1; T19D16.15; T19D16_15
NCBI Protein Information
DNA helicase (RECQl4A)
NCBI Summary
DNA helicase involved in the maintenance of genome stability by modulation of the DNA damage response and suppression of homologous recombination.
UniProt Gene Name
RECQL4A
UniProt Synonym Gene Names
RECQ4A; RQL4A; SGS1; AtRecQ4A; AtRecQl4A; AtSGS1
UniProt Protein Name
ATP-dependent DNA helicase Q-like 4A
UniProt Synonym Protein Names
RecQ-like protein 4A; AtRecQ4A; AtRecQl4A; SGS1-like protein; AtSGS1
UniProt Primary Accession #
Q8L840
UniProt Secondary Accession #
O04092; Q9FT71
UniProt Related Accession #
Q8L840
UniProt Comments
3'-5' DNA helicase involved in DNA repair (PubMed:16146519, PubMed:18000056, PubMed:19096507). Required for the maintenance of genome stability by modulation of the DNA damage response and repression of crossovers. Confers resistance to genotoxic stress (PubMed:16146519, PubMed:18000056). Suppresses spontaneous homologous recombination (HR) events in somatic cells together with its partners RMI1 and TOP3A (PubMed:19096507). Contributes to the maintenance of chromosome integrity during meiosis. Involved in the removal of telomeric bridges that appear to arise during meiotic recombination. Required to resolve or dissolve MSH4-dependent telomeric associations. Does not seem required for chiasma formation (PubMed:21265901).
For research use only, not for clinical use.