NCBI Accession #
NP_189399.1
NCBI GenBank Nucleotide #
NM_113678.2
NCBI Official Full Name
alternative oxidase 1C
NCBI Official Symbol
AOX1C
NCBI Official Synonym Symbols
alternative oxidase 1C; AOX1C
NCBI Protein Information
alternative oxidase 1C
NCBI Summary
encodes an isoform of alternate oxidase. expressed in all tissues examined and expression is not induced by antimycin A, an inhibitor of complex III in the mitochondrial respiratory chain.
UniProt Protein Name
Ubiquinol oxidase 1c, mitochondrial
UniProt Synonym Protein Names
Alternative oxidase 1c
UniProt Entry Name
AOX1C_ARATH
UniProt Primary Accession #
O22048
UniProt Related Accession #
O22048
UniProt Comments
Function: Catalyzes the cyanide-resistant oxidation of ubiquinol and the reduction of molecular oxygen to water, but does not translocate protons and consequently is not linked to oxidative phosphorylation. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures By similarity.Catalytic activity: 2 ubiquinol + O2 = 2 ubiquinone + 2 H2O.Cofactor: Binds 2 iron ions per subunit.Subunit structure: Homodimer; disulfide-linked Probable.Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein Probable. Note: Mitochondrial, possibly in the inner surface of the inner mitochondrial membrane.Tissue specificity: Expressed in roots, stems, leaves, cotyledons and flowers. High expression in stamens.0Developmental stage: Expressed ubiquitously. Not detected during germination.Induction: No effect of antimycin A. Up-regulated by ethylene, high light, glucose, cysteine, mannitol, salicylic acid and cold treatments.123Sequence similarities: Belongs to the alternative oxidase family.