Products
Online Inquiry
Adagio protein 2 (ADO2), Recombinant Protein
Cat: RP02701
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Adagio protein 2 (ADO2) , partial
Product Gene Name
ADO2 recombinant protein
Product Synonym Gene Name
ADO2
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
65,116 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Adagio protein
NCBI/Uniprot Data
NCBI Accession #
NP_565444.2
NCBI GI #
30680514
NCBI GenBank Nucleotide #
NM_127448.2
NCBI GeneID
816408
NCBI Official Full Name
LOV KELCH protein 2
NCBI Official Symbol
LKP2
NCBI Official Synonym Symbols
ADAGIO 2; ADO2; LOV KELCH protein 2
NCBI Protein Information
LOV KELCH protein 2
NCBI Summary
encodes a member of F-box proteins that includes two other proteins in Arabidopsis (ZTL and FKF1). These proteins contain a unique structure containing a PAS domain at their N-terminus, an F-box motif, and 6 kelch repeats at their C-terminus. Overexpression results in arrhythmic phenotypes for a number of circadian clock outputs in both constant light and constant darkness, long hypocotyls under multiple fluences of both red and blue light, and a loss of photoperiodic control of flowering time. Although this the expression of this gene itself is not regulated by circadian clock, it physically interacts with Dof transcription factors that are transcriptionally regulated by circadian rhythm. LKP2 interacts with Di19, CO/COL family proteins.
UniProt Gene Name
ADO2
UniProt Synonym Gene Names
FKL1; LKP2; FBX2c; FKF1-like protein 1
UniProt Protein Name
Adagio protein 2
UniProt Synonym Protein Names
F-box only protein 2c; FBX2c; Flavin-binding kelch repeat F-box protein 1-like protein 1; FKF1-like protein 1; LOV kelch protein 2
UniProt Primary Accession #
Q8W420
UniProt Secondary Accession #
Q9C5S6; B5X4Z7
UniProt Related Accession #
Q8W420
UniProt Comments
Component of an E3 ubiquitin ligase complex that plays a central role in blue light-dependent circadian cycles. Acts as a blue light photoreceptor, due to the presence of FMN, that mediates light-regulated protein degradation of critical clock components by targeting them to the proteasome complex. The SCF(ADO2) E3 ubiquitin ligase complex is involved in the regulation of circadian clock-dependent processes including the transition to flowering time, hypocotyl elongation, cotyledons and leaf movement rhythms. APRR1/TOC1 and APRR5 seem to be substrates of the SCF(ADO2) complex. ADO2 interacts with ADO3 and export it to cytoplasmic speckles, preventing the interaction of ADO3 with CDF1. Ubiquitination of ADO2 is not involved in this recruitment.
For research use only, not for clinical use.