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Adagio protein 1 (ADO1), Recombinant Protein
Cat: RP02204
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Adagio protein 1 (ADO1) , partial
Product Gene Name
ADO1 recombinant protein
Product Synonym Gene Name
ADO1
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
65,906 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Adagio protein
NCBI/Uniprot Data
NCBI Accession #
NP_568855.1
NCBI GI #
18423971
NCBI GenBank Nucleotide #
NM_125119.4
NCBI GeneID
835842
NCBI Official Full Name
Galactose oxidase/kelch repeat superfamily protein
NCBI Official Symbol
ZTL
NCBI Official Synonym Symbols
ADAGIO 1; ADO1; FKF1-LIKE PROTEIN 2; FKL2; LKP1; LOV KELCH PROTEIN 1; MSF19.2; MSF19_2; ZEITLUPE
NCBI Protein Information
Galactose oxidase/kelch repeat superfamily protein
NCBI Summary
Encodes clock-associated PAS protein ZTL; Also known as FKF1-like protein 2 or ADAGIO1(ADO1). A protein containing a PAS domain ZTL contributes to the plant fitness (carbon fixation, biomass) by influencing the circadian clock period. ZTL is the F-box component of an SCF complex implicated in the degradation of TOC1.
UniProt Gene Name
ADO1
UniProt Synonym Gene Names
FKL2; LKP1; ZTL; FBX2b; FKF1-like protein 2
UniProt Protein Name
Adagio protein 1
UniProt Synonym Protein Names
Clock-associated PAS protein ZTL; F-box only protein 2b; FBX2b; Flavin-binding kelch repeat F-box protein 1-like protein 2; FKF1-like protein 2; LOV kelch protein 1; Protein ZEITLUPE
UniProt Primary Accession #
Q94BT6
UniProt Secondary Accession #
Q9LDF6
UniProt Related Accession #
Q94BT6
UniProt Comments
Component of an E3 ubiquitin ligase complex that plays a central role in blue light-dependent circadian cycles. Acts as a blue light photoreceptor, due to the presence of FMN, that mediates light-regulated protein degradation of critical clock components by targeting them to the proteasome complex. The SCF(ADO1) E3 ubiquitin ligase complex is involved in the regulation of circadian clock-dependent processes including the transition to flowering time, hypocotyl elongation, cotyledons and leaf movement rhythms. APRR1/TOC1 and APRR5, but not 'GIGANTEA', are proteolytic substrates of this ubiquitin ligase complex. Blue light enhances cooperative stabilization of 'GIGANTEA' and ADO1/ZTL, leading to amplification and sharpening of the expression profile of APRR1/TOC1. ADO1/ZTL interacts with ADO3, preventing the interaction of ADO3 with CDF1.
For research use only, not for clinical use.