NCBI Accession #
NP_001328232.1
NCBI GenBank Nucleotide #
NM_001342558.1
NCBI Official Full Name
peroxisomal ABC transporter 1
NCBI Official Symbol
ABCD1
NCBI Official Synonym Symbols
acetate non-utilizing 2; ACN2; Arabidopsis thaliana ATP-binding cassette D1; AtABCD1; ATP-binding cassette D1; COMATOSE; CTS; PED3; peroxisomal ABC transporter 1; PEROXISOME DEFECTIVE 3; PXA1; T5J17.20; T5J17_20
NCBI Protein Information
peroxisomal ABC transporter 1
NCBI Summary
Encodes a peroxisomal protein of the ATP binding cassette (ABC) transporter class (PMP subfamily) with significant identity to the human X-linked adrenoleukodystrophy protein (ALDP). The gene product promotes germination and represses embryo dormancy. ABI3, ABA1, FUS3 and LEC1 are epistatic to this gene. Mutants accumulate fatty acyl CoA suggesting a defect in uptake of fatty acyl CoA into the peroxisome.
UniProt Synonym Gene Names
ACN2; CTS; PED3; PMP2; PXA1; ABC transporter ABCD.1; AtABCD1; AtPXA1; Ped3p
UniProt Protein Name
ABC transporter D family member 1
UniProt Synonym Protein Names
Peroxisomal ABC transporter 1; AtPXA1; Protein ACETATE NON-UTILIZING 2; Protein COMATOSE; Protein PEROXISOME DEFECTIVE 3; Ped3p
UniProt Primary Accession #
Q94FB9
UniProt Secondary Accession #
Q8VWH7; Q9SMR8
UniProt Related Accession #
Q94FB9
UniProt Comments
Contributes to the transport of fatty acids and their derivatives (acyl CoAs) across the peroxisomal membrane. Provides acetate to the glyoxylate cycle in developing seedlings. Involved in pollen tube elongation, ovule fertilization, and seeds germination after imbibition (controls the switch between the opposing developmental programs of dormancy and germination), probably by promoting beta-oxidation of storage lipids during gluconeogenesis. Required for biosynthesis of jasmonic acid and conversion of indole butyric acid to indole acetic acid. Confers sensitivity to monofluoroacetic acid (FAc), a toxic acetate analog, and to 2,4-dichlorophenoxybutyric acid (2,4-DB) and indole-3-butyric acid (IBA), two precursors of auxin after beta-oxidation.