5'-3' exoribonuclease 3 (XRN3), Recombinant Protein
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5'-3' exoribonuclease 3 (XRN3), Recombinant Protein

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Cat: RP01569
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana 5'-3' exoribonuclease 3 (XRN3) , partial
Product Gene Name
XRN3 recombinant protein
Product Synonym Gene Name
XRN3
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
88,581 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
5'-3' exoribonuclease

NCBI/Uniprot Data

NCBI Accession #
NP_565114.1
NCBI GI #
18410905
NCBI GenBank Nucleotide #
NM_106217.3
NCBI GeneID
843900
NCBI Official Full Name
5'-3' exoribonuclease 3
NCBI Official Symbol
XRN3
NCBI Official Synonym Symbols
5'-3' exoribonuclease 3; 5'-3' EXORIBONUCLEASE 3; AtXRN3; F10A5.15; F10A5_15
NCBI Protein Information
5'-3' exoribonuclease 3
NCBI Summary
Encodes a protein with similarity to yeast 5'-3'exonucleases and can functionally complement the yeast mutations. In Arabidopsis XRN3 acts as a suppressor of posttranscriptional gene silencing. Mutants accumulate excised miRNA products suggesting that XRN3 is involved in degradation of these products.
UniProt Gene Name
XRN3
UniProt Synonym Gene Names
AtXRN3
UniProt Protein Name
5'-3' exoribonuclease 3
UniProt Synonym Protein Names
Protein EXORIBONUCLEASE 3Curated
UniProt Primary Accession #
Q9FQ03
UniProt Secondary Accession #
Q8L7A3; Q9LR05
UniProt Related Accession #
Q9FQ03
UniProt Comments
Possesses 5'->3' exoribonuclease activity (PubMed:11106401). Acts as an endogenous post-transcriptional gene silencing (PTGS) suppressor. Degrades miRNA-derived loops, excised during miRNA maturation in the nucleus. Required for proper development (PubMed:17993620). Involved in pre-rRNA processing. Involved with XRN2 in the 5'-end exonucleolytic processing of 5.8S and 25S rRNAs. Contributes with XRN2 to polyadenylation-dependent nuclear RNA surveillance. Involved in the degradation of aberrant polyadenylated pre-rRNA through 5'-end processing (PubMed:20338880).

For research use only, not for clinical use.