NCBI Accession #
NP_195178.1
NCBI GenBank Nucleotide #
NM_119617.2
NCBI Official Full Name
3-ketoacyl-CoA synthase 18
NCBI Official Symbol
KCS18
NCBI Official Synonym Symbols
3-ketoacyl-CoA synthase 18; FAE1; FATTY ACID ELONGATION1; T4L20.100; T4L20_100
NCBI Protein Information
3-ketoacyl-CoA synthase 18
NCBI Summary
Encodes KCS18, a member of the 3-ketoacyl-CoA synthase family involved in the biosynthesis of VLCFA (very long chain fatty acids).
UniProt Synonym Gene Names
VLCFA condensing enzyme 18
UniProt Protein Name
3-ketoacyl-CoA synthase 18
UniProt Synonym Protein Names
Protein FATTY ACID ELONGATION 1
UniProt Primary Accession #
Q38860
UniProt Related Accession #
Q38860
UniProt Comments
Contributes to fatty acids elongation and stockage in developing seeds. Active on both saturated and mono-unsaturated acyl-CoAs of 16 and 18 carbons. Required for the elongation of C18 to C20 and of C20 to C22 fatty acids. Mediates also the synthesis of VLCFAs from 20 to 26 carbons in length (e.g. C20:1, C20, C22:1, C22, C24:1, C24, C26) (PubMed:15277688, PubMed:16765910, PubMed:7734965, PubMed:9263455, Ref. 4, Ref. 5, PubMed:12135493, PubMed:23145136). Has no activity with polyunsaturated C18:2 and C18:3 or with acyl-CoAs having 22 carbons or longer chain length (PubMed:12135493).