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3-hydroxyacyl-CoA dehydratase PASTICCINO 2 (PAS2), Recombinant Protein
Cat: RP02636
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana 3-hydroxyacyl-CoA dehydratase PASTICCINO 2 (PAS2), partial
Product Gene Name
PAS2 recombinant protein
Product Synonym Gene Name
PAS2
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
22,414 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
NCBI/Uniprot Data
NCBI Accession #
NP_001078566.1
NCBI GI #
145334369
NCBI GenBank Nucleotide #
NM_001085097.1
NCBI GeneID
830912
NCBI Official Full Name
Protein-tyrosine phosphatase-like, PTPLA
NCBI Official Symbol
PAS2
NCBI Official Synonym Symbols
F12B17.170; F12B17_170; PASTICCINO 2; PEP; PEPINO
NCBI Protein Information
Protein-tyrosine phosphatase-like, PTPLA
NCBI Summary
Protein tyrosine phosphatase-like involved in cell division and differentiation. Interacts with CDKA;1 only in its phosphorylated form, preventing dephosphorylation. Overexpression slowed down cell division in suspension cell cultures at the G2-to-M transition and early mitosis and inhibited Arabidopsis seedling growth. Localized in the cytoplasm of dividing cells but moved into the nucleus upon cell differentiation. Based on complementation of yeast mutant PAS2 has acyl-CoA dehydratase activity. It interacts with CER10, a component of the microsomal fatty acid elongase complex, suggesting a role in synthesis of VLCFAs (very long chain fatty acids).
UniProt Gene Name
PAS2
UniProt Synonym Gene Names
PEP; AtPAS2; HACD; HCD; PEP
UniProt Protein Name
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase PASTICCINO 2
UniProt Synonym Protein Names
3-hydroxyacyl-CoA dehydratase PASTICCINO 2; AtPAS2; HACD; HCD; Protein PEPINO; PEP; Protein tyrosine phosphatase-like protein
UniProt Primary Accession #
Q8VZB2
UniProt Secondary Accession #
Q9LXA0; A8MQH5
UniProt Related Accession #
Q8VZB2
UniProt Comments
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be an anti-phosphatase that prevents CDKA-1 dephosphorylation and activation. Involved in the hormonal control of cell division and differentiation. Required for proliferation control of meristematic and non-meristematic cells. Negative regulator of the cell cycle.
For research use only, not for clinical use.