NCBI Accession #
NP_177544.1
NCBI GenBank Nucleotide #
NM_106063.3
NCBI Official Full Name
2-isopropylmalate synthase 1
NCBI Official Symbol
IMS1
NCBI Official Synonym Symbols
2-isopropylmalate synthase 1; 2-ISOPROPYLMALATE SYNTHASE 1; F2P9.9; F2P9_9; IPMS2; ISOPROPYLMALATE SYNTHASE 2; MAML-3; SOPROPYLMALATE SYNTHASE 2
NCBI Protein Information
2-isopropylmalate synthase 1
NCBI Summary
Encodes an active Arabidopsis isopropylmalate synthase IPMS2. Involved in leucine biosynthesis. Do not participate in the chain elongation of glucosinolates. Expressed constitutively throughout the plant. Loss of IPMS2 can be compensated by a second isopropylmalate synthase gene IPMS1 (At1g18500).
UniProt Synonym Gene Names
IMS1; MAML-3
UniProt Protein Name
2-isopropylmalate synthase 2, chloroplastic
UniProt Synonym Protein Names
2-isopropylmalate synthase 1; Methylthioalkylmalate synthase-like 3
UniProt Primary Accession #
Q9C550
UniProt Secondary Accession #
Q8GWX8
UniProt Related Accession #
Q9C550
UniProt Comments
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). Involved in Leu biosynthesis, but do not participate in the chain elongation of glucosinolates.