Model Creation - CD BioSciences

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Model Creation

Model Creation

A model organism is a non-human species (e.g. bacteria, animals, plants) that is used in a research lab to make scientific discoveries. Animals (e.g. mouse, rat, non-human primate) are the most widely used models, which are often genetically engineered. They are used in medical research to investigate human diseases or in basic research to study the function of genes. Advancing genome editing technologies like CRISPR/Cas9 allow for genome manipulation of animals to study the clinical signs or "phenotype" associated with certain genes.

Generation of bacterium/animal/plant models is time-consuming and complex, but inevitable for investigating the mechanisms of certain regulators in signaling pathways. As an experienced service provider for decades, CD BioSciences offers customized model creation services to help you obtain the best animal models resembling human diseases, or generate genetically engineered organisms of your interest.

Model Creation

Animal Models

We offer model creation services including not only the following species, but also rabbits, gerbils, hamsters, guinea pigs, ferrets and simian species, in your desired genetic background. Besides, we also offer customized Cell Line Engineering services.

Category Model Organism Common Name
Prokaryote,
bacteria
Escherichia coli
(E. coli)
N/A
Eukaryote,
unicellular
Saccharomyces cerevisiae
 (S. cerevisiae)
Budding yeast
Schizosaccharomyces pombe
(S. pombe)
Fission yeast
Plant Arabidopsis thaliana
(A. thaliana)
Thale cress
Animal,
nonvertebrate
Caenorhabditis elegans
(C. elegans)
Worm/Nematode
Drosophila melanogaster
(D. melanogaster)
Fruit fly
Animal,
vertebrate
Danio rerio
(D. rerio)
Zebrafish
Mammal Mus musculus
(M. musculus)
House mouse
Rattus norvegicus
(R. norvegicus)
Rat
Non-human Primate Macaca mulatta
(M. mulatta)
Rhesus macaque

Our Custom Services

Together with our Customized Gene Engineering service, we offer the following genome manipulation in model organisms.

Knockouts
(KO)
Constitutive KO Whole-body knockout, permanently deactivating a target gene therefore the corresponding protein in the organism with CRISPR/Cas9 system.
Conditional KO
  • Tissue-specific KO
    (Spatially controlled knockout, deactivating a target gene in a certain tissue, with Cre/loxP system.)
  • Inducible KO
    (Temporally controlled knockout, deactivating a target gene at a given time-point in embryonic, post-natal or adult animals.)
  • Functional KO
    (Specifically mutating one or more nucleotides in a gene to cause loss of function of the target protein.)
Knockins
(KI)
Constitutive KI Adding a DNA sequence to an endogenous locus in the genome.
Point Mutation KI Specifically mutating one or more nucleotides in a gene to change the function of the target protein (gain/loss of function).
Reporter KI Inserting fluorescent, bioluminescent proteins or biochemical tags to a certain locus in the genome.
Humanization KI Substituting gene sequence in model organisms with the human counterpart.
Knockdowns
(KD)
Precisely controlling in vivo gene expression in organisms with RNA interference or inducible/reversible miRNA expression.
Transgenic
Models
Designing and generating transgenic models to study transgene expression and function.

Advantages of Our Services

Model Creation

One-Stop Service

We are dedicated to providing you with a complete portfolio of research services from gene/protein study to preclinical research and drug discovery. With our model creation service, your models are delivered together with their diets and equipment, to support further research and development.

Model Creation

Large Inventory of Models

With a large number of research model organisms in our inventory, your model organisms will be quickly delivered. Our model creation services are also equipped with qualitative and quantitative genotyping & profiling.

Model Creation

Extensive Experience

As a trusted service provider for decades, our highly experienced scientists discuss your research goals, and personalize the strategy for you. You are guaranteed accurate data and flexibility in subsequent investigations.

Features

CD BioSciences offers cost-effect, high quality and hassle-free model creation services to our clients worldwide. We guarantee to deliver our products and results on time. Please feel free to contact us.

For research use only. Not intended for any clinical use.