Drug Evaluation - CD BioSciences

service-banner

Drug Evaluation

Drug Evaluation

Drug evaluation refers to the study of drug metabolism and pharmacokinetics (DMPK), which is a core discipline within drug discovery and development. DMPK studies the Absorption/Administration, Distribution, Metabolism, and Elimination/Excretion (ADME) properties of chemical compounds to assist the selection of optimal drug candidates. DMPK/ADME also contributes to lead optimization, and compound design. Together with ADME, the potential toxicity of the compound is also taken into consideration, and termed ADMET or ADME-Tox.

With extensive experience, CD BioSciences offers a full range of services for drug candidate evaluation, including in vitro physicochemical profiling and in vivo bioassays to facilitate your drug discovery and development.

drug evaluation

Definition of ADME

ADME is an abbreviation for "absorption/administration, distribution, metabolism, and elimination/excretion", which describes the disposition of a pharmaceutical compound within an organism. In vitro and in vivo DMPK/ADME studies enable researchers to identify drugs with high potential.

drug evaluation
Absorption/Administration

Absorption defines the movement of a drug being taken up the target cells. It critically determines the compound's bioavailability. Chemical compounds differ from each other in physiochemical properties (e.g., molecular weight, solubility) and biochemical characteristics (e.g., membrane permeability, metabolism), which may affect the absorption of a drug.

drug evaluation
Distribution

Distribution refers to the transportation and distribution of the drug after been absorbed. Factors affecting drug distribution include molecular size, polarity, binding target, and drug-drug interactions.

drug evaluation
Metabolism

Metabolism refers to the breakdown of the drug, which plays a major role in both efficacy and safety. Most metabolism of small-molecule drugs takes place in the liver by redox enzymes (i.e., cytochrome P450 (CYP450) enzymes).

drug evaluation
Elimination/Excretion

Excretion refers to the removal of the chemical compounds and their metabolites, which usually through urination.

Our Services

To gain adequate knowledge of a potential chemical compound, a series of drug evaluation assays are required. Have successfully developed a functional drug discovery system, we provide all kinds of drug evaluation services including but not limited to the following.

Absorption/Administration Studies Distribution studies Metabolism studies Elimination/Excretion studies
  • Aqueous Solubility;
  • in vitro Permeability;
  • in vitro Dermal Absorption;
  • in vivo Dermal Absorption;
  • in vivoPharmacokinetics
  • in vitro Uptake Transporter Binding;
  • in vitro Plasma Protein Binding;
  • in vivo Tissue Distribution;
  • in vivo pharmacokinetics
  • Metabolic Stability;
  • Metabolite Profiling;
  • CYP/UGT Characterization;
  • Drug-drug Interaction (DDI);
  • in vitro Efflux Transporter Binding;

Features

CD BioSciences offers cost-effect, high quality and hassle-free drug evaluation services to our clients worldwide. We guarantee to deliver our results on time. Please feel free to contact us.

For research use only. Not intended for any clinical use.