Caspase-8 (Pro and Active) Antibody - CD BioSciences


Caspase-8 (Pro and Active) Antibody

Caspase-8 (Pro and Active) Antibody


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0.025 mL Online Inquiry
0.05 mL Online Inquiry
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Target Information
Target Name Caspase-8
Gene Abbr. CASP8
Gene ID 841
Full Name caspase 8
Alias ALPS2B, CAP4, Casp-8, FLICE, MACH
Introduction Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10. Activated caspase-8 cleaves and activates downstream effector caspases such as caspase-1, -3, -6, and -7. Caspase-3 ultimately elicits the morphological hallmarks of apoptosis, including DNA fragmentation and cell shrinkage.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Isotype IgG
Immunogen Synthetic peptide corresponding to the C-terminus of human Caspase-8 (PQPTFTLRKKLVFPSD). This sequence is common to various Caspase-8 forms including: 1. Caspase 8a (aa 481-496 GenBank no. NP_001219.2) 2. Caspase 8b (aa 464-479, GenBank no. NP_203519.1) 3. Caspase 8c (aa 449-464, GenBank no. NP_203520.1) 4. Caspase 8L (aa 523-538, GenBank no. gbAAL87628.1) 5. Truncated caspase 8 (as 251-266, GenBank no. gi3928274).
Application WB, IHC, IP
Dilutions Western Blot (1:1000-1:2000); Immunohistochemistry (1:10-1:500); Immunoprecipitation (1:50-1:200)
MW(KDa) 18, 43, 57
Reactivity Human, Mouse, Rat
Specificity Caspase-8.
Storage & Handling
Storage Buffer Whole antisera.
Preservative 0.05% Sodium Azide
Storage Temp. Store at -20 °C.
Handling Avoid freeze-thaw cycles.

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