Caspase-8 Antibody - CD BioSciences


Caspase-8 Antibody

Caspase-8 Antibody


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Target Information
Target Name Caspase-8
Gene Abbr. CASP8
Gene ID 841
Full Name caspase 8
Alias ALPS2B, CAP4, Casp-8, FLICE, MACH
Introduction Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10. Activated caspase-8 cleaves and activates downstream effector caspases such as caspase-1, -3, -6, and -7. Caspase-3 ultimately elicits the morphological hallmarks of apoptosis, including DNA fragmentation and cell shrinkage.
Product Details
Host Mouse
Clonality Monoclonal
Clone No. FLICE4-1-20
Isotype IgG1 Kappa
Immunogen Full-length recombinant human Caspase 8 [UniProt# Q14790].
Application WB
Dilutions Western Blot (1:1000)
MW(KDa) 18, 43, 57
Reactivity Human, Mouse
Storage & Handling
Storage Buffer Ascites.
Preservative 0.1% Sodium Azide
Storage Temp. Store at 4 °C.
Handling Do not freeze.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.