Caspase-8 Antibody - CD BioSciences


Caspase-8 Antibody

Caspase-8 Antibody


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Target Information
Target Name Caspase-8
Gene Abbr. CASP8
Gene ID 841
Full Name caspase 8
Alias ALPS2B, CAP4, Casp-8, FLICE, MACH
Introduction Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10. Activated caspase-8 cleaves and activates downstream effector caspases such as caspase-1, -3, -6, and -7. Caspase-3 ultimately elicits the morphological hallmarks of apoptosis, including DNA fragmentation and cell shrinkage.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Isotype IgG
Immunogen Recombinant protein encompassing a sequence within the center region of human Caspase 8.
Application WB, IF, IHC
Dilutions Western Blot (1:500-1:3000); Immunofluorescence (1:100-1:1000); Immunohistochemistry (1:100-1:1000)
MW(KDa) 18, 43, 57
Reactivity Human, Mouse, Rat
Validation Knockout Validated.
Storage & Handling
Storage Buffer PBS, 20% Glycerol (pH 7).
Preservative 0.025% Proclin 300
Storage Temp. Aliquot and store at -20 °C or -80 °C.
Handling Avoid freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.