Caspase-8 Antibody - CD BioSciences

service-banner

Caspase-8 Antibody

Caspase-8 Antibody

SPA-01426

Size Price
25 µg Online Inquiry
100 µg Online Inquiry
More Options Online Inquiry
Target Information
Target Name Caspase-8
Gene Abbr. CASP8
Gene ID 841
Full Name caspase 8
Alias ALPS2B, CAP4, Casp-8, FLICE, MACH
Introduction Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10. Activated caspase-8 cleaves and activates downstream effector caspases such as caspase-1, -3, -6, and -7. Caspase-3 ultimately elicits the morphological hallmarks of apoptosis, including DNA fragmentation and cell shrinkage.
Product Details
Host Mouse
Clonality Monoclonal
Clone No. 90A992
Isotype IgG1
Immunogen The immunogen for this product falls between amino acids 360-385 of the human Caspase 8 protein.
Usage
Application WB, FC, IHC
Dilutions Western Blot (0.5-2 µg/mL); Flow Cytometry (0.1-0.5 µg/mL)
MW(KDa) 18, 43, 57
Reactivity Human, Primate
Specificity This can be used for detection of the pro-form of Caspase-8.
Storage & Handling
Storage Buffer PBS.
Preservative 0.05% Sodium Azide
Storage Temp. Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage.
Handling Avoid freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.