Caspase-8 (active/cleaved) Antibody - CD BioSciences


Caspase-8 (active/cleaved) Antibody

Caspase-8 (active/cleaved) Antibody


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0.025 mL Online Inquiry
0.05 mL Online Inquiry
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Target Information
Target Name Caspase-8
Gene Abbr. CASP8
Gene ID 841
Full Name caspase 8
Alias ALPS2B, CAP4, Casp-8, FLICE, MACH
Introduction Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10. Activated caspase-8 cleaves and activates downstream effector caspases such as caspase-1, -3, -6, and -7. Caspase-3 ultimately elicits the morphological hallmarks of apoptosis, including DNA fragmentation and cell shrinkage.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Isotype IgG
Immunogen Recombinant catalytically active human Caspase-8 protein.
Application WB, FC, IF, IHC, IP
Dilutions Western Blot (1:1000-1:2000); Immunofluorescence (1:10-1:500); Immunohistochemistry (1:10-1:500); Immunoprecipitation (1:50-1:200)
MW(KDa) 18, 43, 57
Reactivity Human, Mouse, Rat, Mammal
Specificity This is specific for the active (cleaved) Caspase 8 protein, both large (17-21 kDa) and small (10-13 kDa) subunits.
Storage & Handling
Storage Buffer Whole antisera.
Preservative 0.05% Sodium Azide
Storage Temp. Store at -20 °C.
Handling Avoid freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.